Efficacy and Safety of Fermented Barley on Decrement of Body Fat in Obese Subjects

Chonbuk National University Hospital80 enrolled

Overview

Barley, like oats, is a rich source of the soluble fibre β-glucan, which has been shown to significantly lower LDL-cholesterol (LDL-C). However, barley foods have been less widely studied.

This study investigated whether the supplementation of barley β-glucan is reduce the visceral fat as well as the serum low-density lipoprotein cholesterol (LDL-C) and total cholesterol (TC) in mildly hypercholesterolemic subjects. In a 12 week double-blind, controlled study, subjects were randomized to one of treatment group(3.0g/day as β-glucan) or placebo group.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

DOUBLE

Enrollment

Conditions

Overweight; Hyperlipidemia

Interventions

Barley beta-glucan(3.0g)DIETARY_SUPPLEMENT

Barley beta-glucan(3.0g/day) for 12 weeks

PlaceboDIETARY_SUPPLEMENT

Placebo for 12 weeks

Eligibility

Sex: ALLMin age: 19 YearsMax age: 70 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * an age from 19 to 70 years, * a BMI(Body Mass Index) \>23 kg/m\^2, * an LDL-C(Low Density Lipoprotein-cholesterol) concentration between 110 and 250 mg/dL Exclusion Criteria: * they had heart disease, liver or kidney disease, food allergies, daily exercise habits, a body weight increase or decrease \>10 kg in the previous 3 months, irregular lifestyle habits * they took medication and functional foods known to affect lipid metabolism.

Locations (1)

Clinical Trial Center for Functional Foods; Chonbuk National University Hospital

Jeonju, Jeollabuk-do, South Korea

Outcomes

Primary Outcomes

Changes in Body Fat Mass(kg)

Body fat mass(kg) was measured in study visit 1(0 week) and visit 3(12 week).

Time frame: 12 weeks

Changes in Percent Body Fat(%)

Percent body fat(%) was measured in study visit 1(0 week) and visit 3(12 week).

Time frame: 12 weeks

Secondary Outcomes

Changes in Visceral Adipose Tissue

Visceral adipose tissue was measured in study visit 1(0 week) and visit 3(12 week).

Time frame: 12 weeks

Changes in LDL-C (LDL Low Density Lipoprotein-cholesterol)

LDL-C (LDL Low Density Lipoprotein-cholesterol) was measured in study visit 1(0 week) and visit 3(12 week).

Time frame: 12 weeks

Changes in HDL-C(High Density Lipoprotein-cholesterol)

HDL-C(High Density Lipoprotein-cholesterol) was measured in study visit 1(0 week) and visit 3(12 week).

Time frame: 12 weeks

Changes in Total Cholesterol

Total cholesterol was measured in study visit 1(0 week) and visit 3(12 week).

Time frame: 12 weeks

Changes in Triglyceride

Triglyceride was measured in study visit 1(0 week) and visit 3(12 week).

Time frame: 12 weeks

Changes in FFA(Free Fatty Acid)

FFA(free fatty acid) was measured in study visit 1(0 week) and visit 3(12 week).

Data from ClinicalTrials.gov

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