System for Measuring Non-invasive Blood Flow in the Tracheobronchial Mucosa: Validation of Reproducibility

Centre Hospitalier Universitaire de Nīmes

Overview

The primary objective of this study is to evaluate the reproducibility of a method of measuring blood flow rates to the tracheo-bronchial mucosa using diluted dimethyl ether as a tracer.

Study Type

INTERVENTIONAL

Allocation

Purpose

DIAGNOSTIC

Masking

NONE

Conditions

Healthy

Interventions

Blood flow to the tracheo-bronchial mucosaBIOLOGICAL

Measurement of blood flow to the tracheo-bronchial mucosa via differential absorption of diluted dimethyl ether tracer gas.

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * The patient must have given his/her informed and signed consent * The patient must be insured or beneficiary of a health insurance plan Exclusion Criteria: * The patient is under judicial protection, under tutorship or curatorship * The patient refuses to sign the consent * It is impossible to correctly inform the patient * Patient is pregnant * Patient is breast feeding * The patient is a smoker * The patient has, or has a history of, chronic respiratory insufficiency * The patient has a contra-indication for a treatment necessary in this study

Outcomes

Primary Outcomes

The reproducibility of two measures of Qaw at a five minute interval

Qaw is the blood flow measured in the tracheobronchial mucosa. Qaw = VDME/(FDME\*alpha\*10s) where VDME is the volume of dimethyl-ether exhaled (ml), FDME is the mean concentration of dimethyl-ether (%), alpha is the Bunsen coefficient for the dissolution of dimethyl ether in tissues and blood at 37°C (i.e. 9ml/ml).

Time frame: Five minutes

Secondary Outcomes

The time necessary to complete one measure of Qaw (minutes)

Qaw = blood flow measured in the tracheobronchial mucosa

Time frame: Day 1

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.