Pitavastatin, a representative statin-series anti-dyslipidemic drug, and Valsartan, a representative ARB-series anti-hypertensive drug, have been authorized for use also in South Korea. They have been tested in many countries and proved to be effective and safe. The concurrence of dyslipidemia and hypertension has a higher rate, hence statin-series drugs and antihypertensive drugs are simultaneously administered to such patients. The combined administration of statin-series drugs and CCB-series drugs have.
This clinical trial was conducted to evaluate the safety and effectiveness of the combined administration of Pitavastatin and Valsartan to ethnic Koreans with dyslipidemia concurrent with hypertension, as well as to research the influence on the pharmacodynamic interaction between the two drugs.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
150
pitavastatin 4mg/day 8 week valsartan 320mg/day 8 week
Chungbuk National University Hospital
Chungju, South Korea
Konyang University Hospital
Daejeon, South Korea
Asan Medical Center
Seoul, South Korea
Gangnam Severance Hospital
Seoul, South Korea
The experimental group should be compared with control group in the change of DBP and LDL-C on the basis of the baseline.
Time frame: 8 week
Change from Baseline in Systolic Blood Pressure at 6 months.
Time frame: 8 week
The changes and rate of lipid variables (TG, TC, HDL cholesterol and apolipoprotein B)
Time frame: 8 week
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