Metabolomics of systemic psoriasis treatment
Study Type
OBSERVATIONAL
Enrollment
34
Withdrawal of venous blood samples (approx. 20 ml) and 2 skin biopsies (5 mm) Laboratory measurements: Fasting serum concentrations of 200 metabolites covering a biologically relevant panel of amino acids, sugars, acylcarnitines and phospholipids Genome-wide expression profiles generated from RNA derived from peripheral leukocytes
Department of Dermatology and Allergy, Uniklinik Kiel
Kiel, Schleswig-Holstein, Germany
Analysis of metabolic profiles associated with treatment response
The primary aim of this study is to analyze metabolic profiles as well as expression data in patients with chronic plaque psoriasis undergoing systemic treatment with TNF\_-inhibitor agents (etanercept, adalimumab, infliximab) and fumaric acid ester (FAE) in order to identify clinical and metabolomic markers that underlie variability in response to therapy.
Time frame: week 0 and week 12
Identification of metabolomic signatures associated with psoriasis
The secondary aim is to identify metabolomic signatures associated with psoriasis and to identify possible treatment-specific metabolomic signatures. It is anticipated, to get insights into mechanisms of anti-TNF drug action and response as well as first indications for metabotypes that are associated with psoriasis. In addition, genetic variants correlated to these metabotypes might be identified.
Time frame: week 0 and week 12
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