The Efficacity of Hemodiafiltration Versus Hemofiltration for Renal Insufficiency During Intensive Care

Centre Hospitalier Universitaire de Nīmes163 enrolled

Overview

The primary objective of this study is to compare the efficacity of hemodiafiltration and hemofiltration for decreasing plasma urea at 12h among intensive care patients. Secondary objectives include comparing urea clearance, filter duration, and %down-time, between the two techniques.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

163

Conditions

Renal Failure, Acute

Interventions

Hemodiafiltration firstPROCEDURE

Patients will alternate consecutive dialysis sequences between hemodiafiltration and hemofiltration, but starting with hemodiafiltration.

Hemofiltration firstPROCEDURE

Patients will alternate consecutive dialysis sequences between hemodiafiltration and hemofiltration, but starting with hemofiltration.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * According to RIFLE score, patient is stage 'F' * The patient must be insured or beneficiary of a health insurance plan * The patient meets at least one of the following criteria: * metabolic acidosis (pH \< 7.2), excluding keto-acidosis * plasma urea \> 25 mmol/l * hyper-hydration is not controlled by diuretics Exclusion Criteria: * Chronic, terminal renal insufficiency with dialysis * The patient is under judicial protection, under tutorship or curatorship * Suspect hyperkaliemia (Kaliemia \> 6.5 mmol/l with electrocardiographic effects) * Intoxications treated via dialysis * Pregnant, lactating, parturient women * Medical indication for localized citrate anticoagulation * dialysis of less than 12 h * patient or representative refuses to participate

Locations (1)

Centre Hospitalier Universitaire de Nîmes

Nîmes, Gard, France

Outcomes

Primary Outcomes

Proportion of dialysis sequences for which the rate of plasma urea reduction > 60%.

Proportion of dialysis sequences for which the rate of plasma urea reduction \> 60%. Rate of plasma urea reduction = (initial urea concentration - urea concentration after 12h our dialysis)/initial urea concentration.

Time frame: 12 hours

Secondary Outcomes

Proportion of dialysis sequences for which the rate of plasma urea reduction > 60%.

Time frame: 24 hours

Urea clearance (ml/min) for the dialysis sequence under study

Urea clearance (ml/min) for the dialysis sequence under study.

Time frame: 12 hours

Filter lifespan (hours) for the dialysis sequence under study.

Time frame: 12 hours.

The percentage down-time for the first 24 hours of dialysis

The percentage down-time for the first 24 hours of dialysis = (number of hours where the exchange is not effective / 24 hours)\*100

Time frame: 24 hours

Fluid replacement (yes/no)

Was fluid replacement necessary during the studied dialysis sequence?

Time frame: 12 hours

Fluid replacement (yes/no)

Was fluid replacement necessary during the studied dialysis sequence?

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.