SOX as Salvage Treatment in Nasopharyngeal Carcinoma

Inclusion Criteria: * Age range: 18-75 years old * Histological confirmed incurable relapsed or metastatic nasopharyngeal carcinoma * Prior exposure of at least one line of platinum-containing regimen * ECOG performance status 0-1 * Life expectancy of more than 3 months * Bone marrow function: ANC≧1.5×109/L, PLT≧100×109/L, Hb≧80g/L * Liver function: total bilirubin, ALT and AST \<1.5×UNL * Renal function: Cr\<1.5×UNL, CCR≧50ml/min * Without \> 1 grade of neuropathy Exclusion Criteria: * With curable treatment option * With CNS involvement * Prior platinum exposure only in neo-adjuvant/adjuvant setting or concurrently used with radiotherapy * Treated with \> 2 lines of palliative chemotherapy * With prior exposure of S-1 or oxaliplatin * History of other malignancies except cured basal cell carcinoma of skin and carcinoma in-situ of uterine cervix * Significant active infection * Pregnant or lactating women