Carotenoid Response to the Intake of Vegetables and Fruits

USDA Grand Forks Human Nutrition Research Center29 enrolled

Overview

The purpose of this study is to validate the non-invasive tool, resonance Raman spectroscopy for assessing vegetable and fruit consumption.

This study will validate the use of resonance Raman spectroscopy to assess vegetable and fruit intake by performing a controlled feeding study during which volunteers will consume a provided diet with known amounts of carotenoids in the form of fruits and vegetables.

Study Type

INTERVENTIONAL

Allocation

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Resonance Raman Spectroscopy for Dietary Carotenoid Intake

Interventions

Carotenoid DepletionOTHER

Depletion of carotenoids using a restricted food list

Carotenoid RepletionOTHER

Carotenoid repletion with provided diet based on dietary guidelines.

Carotenoid DepletionOTHER

Carotenoid depletion using a restricted food list.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Men and women aged 18 - 65 years * Weight stable (±5 lbs) for at least 2 months prior to the start of the study * Body mass index (BMI) between 19-30 kg/m2 * Willing to refrain from the use of nicotine and dietary supplements for the duration of the study * Willing to maintain baseline weight and physical activity levels Exclusion Criteria: 1. BMI greater than 30. 2. Gastrointestinal disorders, disease, or medication that affects carotenoid absorption or storage 3. Current smoker 4. Allergies or intolerances to foods to be utilized in the study 5. Consumption of greater than an average of 1 alcoholic drink/day for women and 2/day for men, use of nutritional/sports supplements (if unwilling to discontinue during the study) 6. Pregnancy or lactating

Locations (1)

Grand Forks Human Nutrition Research Center

Grand Forks, North Dakota, United States

Outcomes

Primary Outcomes

Serum and skin levels of carotenoids in adults fed a high carotenoid diet

Time frame: 28 weeks

Data from ClinicalTrials.gov

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