The objective of this study is to show that, in patients undergoing carotid endarterectomy, brain damage, assessed by the determination of S100B before removing the clamp, is less severe with a balanced anesthesia consisting of remifentanil combined with Xenon (experimental arm) compared with remifentanil anesthesia associated with propofol (reference arm).
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Enrollment
86
Patients undergo anesthesia with xenon (remifentanil with xenon).
Patients undergo standard anesthesia (remifentanil with propofol)
Centre Hospitalier Universitaire de Nîmes
Nîmes, Gard, France
Presence/absence of S100B > 0.2 ng/ml during surgery
Presence/absence of S100 calcium binding protein B concentration after induction and before the removal of the radial arterial catheter clamp placed before induction
Time frame: During surgery (expected mean time of around 120 minutes)
S100B change relative to baseline
The change in S100 calcium binding protein B concentration before and after surgery (ng/ml)
Time frame: end of surgery (expected mean of 120 minutes)
NSE change from baseline
The change in Neuron Specific Enolase (NSE) between a preoperative measurement and a second measurement near the end of surgery and just before clamp removal
Time frame: end of surgery (expected mean of 2 hours), just before clamp removal
NSE change from baseline
The change in Neuron Specific Enolase (NSE) between a preoperative measurement and a second measurement just after surgery
Time frame: end of surgery (expected mean of 2 hours)
Change in troponine from baseline
Change in tropinine between preoperative and postoperative measurements
Time frame: end of surgery (expected mean of 2 hours)
Change in creatinemia from baseline
Change in creatinemia between preoperative and postoperative measurements
Time frame: end of surgery (expected mean of 2 hours)
Change in creatine clearance from baseline
Change in creatine clearance (MDRD equation) between preoperative and postoperative measurements
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Time frame: end of surgery (expected mean of 2 hours)
Change NIHSS score from baseline
Change in the National Institute of Health Stroke Score (NIHSS) between preoperative and postoperative measurements
Time frame: end of surgery (expected mean of 2 hours)
Number of transfusions
Number of transfused red blood cell packs
Time frame: During surgery (estimated mean of 120 minutes)
Direct costs
Direct costs (€) incurred
Time frame: 2 days
Indirect costs
The indirect costs (€) incurred
Time frame: 2 days