The Hemolytic Uremic Syndrome (HUS) in its typical form occurs after a food born infection with a shiga-toxin secreting bacteria, usually Escherichia coli of the O157H7 serotype. An outbreak of bloody diarrhea followed by HUS begun after a collective meal with 120 persons on June 8th, 2011 in Bègles, a city of Bordeaux urban area (CUB). At least 9 patients, 8 adults and 1 child have been involved in this HUS outbreak, E. coli of the O104:H4 serotype being demonstrated in most patients. This outbreak is remarkable by its preponderance in adults and women, its aggressiveness with multiorgan involvement , i.e. the kidneys, brain, liver, pancreas, and skin. Pathophysiology, prognosis, and treatment of typical HUS are poorly defined, particularly in adults who are usually not involved in typical E. coli O157H7 HUS. The aim of the present study is to gain knowledge on these different aspects of the HUS, including response to therapy.
Study Type
OBSERVATIONAL
Enrollment
9
HUS standard coverage care : plasmaphereses - eculizumab - Immunoadsorption
Service de Néphrologie, transplantation dialyse - Hôpital Pellegrin
Bordeaux, France
Improve scientific knowledge on epidemic HUS in the context of an outbreak of E. coli O104:H4 HUS in the town of Bègles, urban area of Bordeaux, France
This is an observational propspective study in which all data will be collected on all pertinent aspects of disease, including therapeutic regimens.
Time frame: during patient hospitalization
evaluate efficiency of therapeutic and diagnostic strategies
Time frame: during patient hospitalization
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