Running Effect on Cardiovascular and Muscular Parameters

University of Erlangen-Nürnberg Medical School80 enrolled

Overview

The purpose of the study is to determine the effect of 16 weeks of running exercise on various parameters related to heart, vascular systems, blood, and muscle in untrained males 30-50 years old. Further, the investigators assess which of the above mentioned parameters may explain the increase of running performance most accurate.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Males Untrained 30-50 Years Old Healthy

Interventions

exerciseOTHER

16 week of periodized progressive running exercise 2-4 times/week

Eligibility

Sex: MALEMin age: 30 YearsMax age: 50 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * males * untrained (\< 2 endurance exercise sessions/week) * 30-50 years old Exclusion Criteria: * pathological changes of the heart * inflammable diseases * medication/diseases affecting cardiovascular system and muscle * very low physical capacity (\< 100 Watt at ergometry) * obesity (BMI \> 30 kg/m2) * more than 2 weeks of absence during the interventional period * more than 2 exercise session beside the intervention * contraindication related to MRI-assessment (i.e. claustrophobia, magnetizable intracorporal artefacts)

Locations (3)

Institute of Medical Physics, University of Erlangen-Nurnberg

Erlangen, Germany

Institute of Physical Education and Sport Sciences

Erlangen, Germany

Departement of Radiology, University of Erlangen-Nurnberg

Erlangen, Germany

Outcomes

Primary Outcomes

myocardial mass/stroke volume

Atrial and ventricular volume and mass indexes were assessed by magnetic resonance imaging (MRI)

Time frame: 4 month

Secondary Outcomes

maximal oxygen uptake

maximal oxygen uptake during running

Time frame: 4 month

Resting metabolic rate

Adaptation of resting metabolic rate to running exercise

Time frame: 4 month

muscle strength/power

Isometric muscle strength of the leg extensors Leg power as assessed by counter movement jump

Time frame: 4 month

myocardial volume

Functional and morphologic parameters of the heart as assessed by echocardiography

Time frame: 4 month

Intima media thickness

Carotid intima media thickness by high-resolution ultrasound

Time frame: 4 month

Data from ClinicalTrials.gov

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