Protein Expression in Human Neuroblastoma Tumor Samples

Children's Oncology Group20 enrolled

Overview

RATIONALE: Studying protein expression in samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. It may also help doctors find better ways to treat neuroblastoma. PURPOSE: This laboratory studying is looking at protein expression in tumor tissue samples from patients with neuroblastoma.

OBJECTIVES: * To determine whether intersectin (ITSN1) proteins are present at elevated levels in primary human tumor samples. OUTLINE: Archived tumor tissue samples are analyzed for intersectin (ITSN1) expression by western blot assays with enhanced chemiluminescence and exposed to X-ray film. The films are scanned, and levels of ITSN1 signal are quantified by densitometry.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Neuroblastoma

Interventions

protein expression analysisGENETIC

western blottingGENETIC

laboratory biomarker analysisOTHER

Eligibility

Sex: ALL

Medical Language ↔ Plain English

DISEASE CHARACTERISTICS: * Diagnosed with neuroblastoma * Banked primary tumor samples from patients with stage 1, 2, 3, and 4 disease PATIENT CHARACTERISTICS: * Not specified PRIOR CONCURRENT THERAPY: * Not specified

Outcomes

Primary Outcomes

ITSN1 is highly expressed in neuroblastoma tumors and plays an important role in the development/progression of these tumors

Data from ClinicalTrials.gov

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