Efficacy and Safety of Artesunate-amodiaquine-methylene for Malaria Treatment in Children

Inclusion Criteria: * 6-59 months old children (male and female) * Weight ≥ 6kg * Uncomplicated malaria caused by P. falciparum * Asexual parasites ≥ 2 000/µl and ≤ 200 000/µl * Axillary temperature ≥ 37.5°C or a history of fever during last 24 hours * Burkinabe nationality * Permanent residence in the study area with no intention of leaving during the surveillance period * Informed consent Exclusion Criteria: * Severe malaria (WHO 2000) * Vomiting (3 or more within 24 hours before the visit) * Any apparent significant disease, including severe malnutrition * A history of a previous, significant adverse reaction to either of the study drugs * Anaemia (haemoglobin \< 7 g/dl) * Treated in the same trial before * All modern antimalarial treatment prior to inclusion (last seven days) * Simultaneous participation in another investigational study * Treatment with other investigational drugs