Gemcitabine-UFTE Chemotherapy in Refractory Colorectal Cancer

Inclusion Criteria: * Age: ≥ 18 years old * ECOG performance status: 0 to 2 * Pathologically proven adenocarcinoma of colorectum * Patients who had received all cytotoxic drugs of 3 categories (fluoropyrimidine \[5-FU, capecitabine or S-1 etc.\], oxaliplatin and irinotecan). * Refractory MRCRC that progressed while receiving, or within 6 months after the discontinuation of all of fluoropyrimidine, oxaliplatin and irinotecan. When retry of fluoropyrimidine, oxaliplatin or irinotecan is not possible due to previous severe toxicities despite progression-free interval ≥ 6 months, patients can be enrolled into this study. * Patients who were previously treated with cetuximab or to whom cetuximab cannot be used (i.e. K-ras mutant or economical problems) * At least one measurable lesion should exist (RECIST version 1.1) Exclusion Criteria: * Patients who had not previously received all of fluoropyrimidine, oxaliplatin and irinotecan will be excluded. * Patients who had received UFTE chemotherapy previously. However, if UFTE chemotherapy was used as adjuvant chemotherapy and the disease-free interval was greater than 6 months, the patient can be included into this study. * Patients receiving active or passive immunotherapy * Patients with complete bowel obstruction or progressive symptoms of partial bowel obstruction that interfere with adequate oral diet. * Patients with large amount of ascites requiring frequent therapeutic paracentesis (\> once per week) * Pregnant or breast-feeding women (a pregnancy test must be performed on all female patients who are of child-bearing potential before entering the study) * Women of child-bearing potential who are unwilling or unable to use an acceptable method to avoid pregnancy for the entire study period. Sexually active fertile men not using effective birth control during the study if their partners are women of child-bearing potential * Serious concurrent infection or nonmalignant illness that is uncontrolled or whose control may be jeopardized by complications of study therapy (i.e., uncontrolled infection, uncontrolled epilepsy, cerebrovascular accidents within the past 6 months, neurologic or psychological disease interfering with study treatment) * Inadequate cardiovascular function: * New York Heart Association class III or IV heart disease, * Unstable angina or myocardial infarction within the past 6 months, * Symptomatic coronary artery disease * History of significant ventricular arrhythmia requiring medication with antiarrhythmics or significant conduction system abnormality * Symptomatic severe interstitial lung disease or pulmonary fibrosis * Patients with impaired renal function: Creatinine clearance \< 50mL/min (calculated by Cockcroft and Gault formula) * Patients with laboratory results as follows; * Number of absolute neutrophil counts (ANC) \< 1.5 x 10\^9/L * Number of thrombocytes \< 100 x 10\^9/L * Total bilirubin \> 1.5 x upper limit of normal * ALAT, ASAT \> 3 x upper limit of normal (in the cases with liver metastasis, \> ALAT, ASAT \> 5 x upper limit of normal) * Alkaline phosphatase \> 3 x upper limit of normal (in the cases with liver or bone metastasis, \> 5 x upper limit of normal) * Major surgery within 4 weeks of start of study treatment, without complete recovery * Patients who were included to other clinical trials within the past 4 weeks.