Vitamin D and HIV-Cardiovascular Disease in Children and Young Adults

N/ACompletedNCT01410305

University Hospitals Cleveland Medical Center290 enrolled

Overview

The relationship of Vitamin D levels in children and young adults to atherosclerosis.

Study Type

OBSERVATIONAL

Enrollment

290

Conditions

Vitamin D Deficiency

Eligibility

Sex: ALLMin age: 8 YearsMax age: 25 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria - Documentation of HIV Infection Between ages of 8 and 25 * On stable ART for at least 12 weeks for the HIV+ patients * Cumulative duration of ART for at least 48 weeks for HIV + patients * Healthy child/young adult with age and race matched to HIV+ patient for the HIV- controls * Absence of HIV based on medical and medication history Exclusion Criteria: * Taking \> 800 IU of Vitamin D per day * Parathyroid or Calcium disorders * Acute illness and active inflammatory condition * Chronic illnesses that include malignancy, diabetes, CAD * Pregnancy and lactation * Creatinine Clearance \<50 ml/min * Hgb \< 9.0 g/dL * AST and ALT \> 2.5 upper limits of normal

Locations (2)

Emory Chldren's Center

Atlanta, Georgia, United States

University Hospitals Case Medical Center, Case Western Reserve University

Cleveland, Ohio, United States

Outcomes

Primary Outcomes

Vitamin D levels

To perform a cross-sectional analysis of blood vitamin D status among the HIV-infected children and young adults to evaluated the point prevalence fo plasma 25(OH)D levels indicating vitamin D insufficiency, deficiency and severe deficiency, and to compare the prevalence to a matched uninfected healthy control group.

Time frame: One time point at entry

Data from ClinicalTrials.gov

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