Continuous Endostar Infusion Combined With Radiotherapy in Patients With Brain Metastases

Inclusion Criteria: * Histologically confirmed malignancy with presence of intraparenchymal brain metastases * Karnofsky performance status ≥ 40 * Measurable disease according to RECIST criteria * Hematologic function: WBC ≥ 4.0×109/L, PLT ≥ 80×109/L, Hb ≥ 90g/L * Renal function: Cr ≤ 2.0×ULN * Hepatic function: BIL ≤ 2.0×ULN, ALT/AST ≤ 5.0×ULN * Adequate cardiac function * Life expectancy ≥ 3 months Exclusion Criteria: * Evidence of bleeding diathesis or serious infection * Serious cardiovascular disease (congestive heart failure, uncontrollable arrhythmia, unstable angina, myocardial infarction, serious heart valve disease, resistant hypertension) * Uncontrollable mental and nervous disorders * Pregnant or lactating women