This study is designed to assess the pathophysiology of ST by studying the main procedural and anatomical factors involved in the genesis of ST such as those related to stent and the vascular wall, as well as to the individual platelet residual reactivity.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
20
OCT guided PCI. Only thrombectomy in case of negative OCT findings (other than uncovered struts).
OCT guided medical therapy. Tailored antiplatelet therapy.
Careggi Hospital, Department of Hearth and Vessels
Florence, Italy
Percentage of uncovered stent struts
The percentage of uncovered stent struts by OCT in patients with subacute stent thrombosis (either DES and BMS) and the percentage of uncovered stent struts in patients with late (after one month) and very late thrombosis of DES.
Time frame: After thrombectomy
Percentage of malapposed stent struts
The percentage of malapposed stent struts by OCT in patients with subacute thrombosis of DES and BMS and the percentage of malapposed stent struts by OCT in patients with late and very late thrombosis of DES.
Time frame: After Thrombectomy
Percentage of patients with high residual platelet reactivity
The percentage of patients with residual platelet reactivity (RPR) to ADP and arachidonic acid identified by values ≥ 240 P2Y12 reaction units (PRU) and ≥ 550 aspirin reaction units (ARU), respectively,. during aspirin and clopidogrel therapy or in which one or both the antiplatelet drugs have been interrupted.
Time frame: Baseline
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