Effect of Saccharomyces Boulardii on Indirect Hyperbilirubinemia and Phototherapy Duration in Very Low Birth Weight Infants

Zekai Tahir Burak Women's Health Research and Education Hospital80 enrolled

Overview

Indirect hyperbilirubinemia is frequently observed in premature infants.Probiotics are favorable microorganisms that regulate the flora of the gastrointestinal system. In this study we aimed to compare the effect of S. boulardii on severity of hyperbilirubinemia and duration of phototherapy on very low birth weight infants.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

SINGLE

Enrollment

Conditions

Indirect Hyperbilirubinemia

Interventions

ReflorDIETARY_SUPPLEMENT

5 million unit/day, first 15 day of life

serum physiologicOTHER

1 cc added to one feeding in a day

Eligibility

Sex: ALLMin age: 1 DayMax age: 15 Days

Medical Language ↔ Plain English

Inclusion Criteria: * very low birth weight infants Exclusion Criteria: * chromosomal anomalies

Locations (1)

Zekai Tahir Burak Maternity Teaching Hospital, Division of Neonatology

Ankara, Turkey (Türkiye)

RECRUITING

Outcomes

Primary Outcomes

Effect of S. boulardii on severity of hyperbilirubinemia and phototherapy duration

Time frame: 6 months

Secondary Outcomes

long term effect of S.boulardii on neurodevelopmental outcome

Time frame: 6 months

Central Contacts

Gamze Demirel, MD

CONTACT

+905324540156 kgamze@hotmail.com

Data from ClinicalTrials.gov

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