The purpose of this study is to investigate the effects of a Nordic diet rich in plant-based foods and fish on indicators of cardiovascular disease risk at two different levels of salt intake. The study is a 20-wk randomized controlled crossover trial. The subjects follow a salt-restricted diet during the study. The study begins with a 4-wk run-in phase for all subjects. After that the subjects are randomly allocated to one of two groups. Group 1 consumes a healthy Nordic low-salt diet enriched with plant-based foods and fish for 16 weeks. Group 2 consumes a low-salt diet for 16 weeks. During the 16 weeks, both groups receive salt and placebo capsules in a double-blind, crossover fashion (8+8 weeks).
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
111
The intervention lasts for 20 weeks and it includes dietary counseling concerning salt restriction. Key foods are provided to the subjects.
National Institute for Health and Welfare
Helsinki, Finland
Change from baseline in systolic and diastolic blood pressure after treatments
Time frame: 12 and 20 weeks
Change from baseline in PFA-100 measurements after treatments
Time frame: 12 and 20 weeks
Change from baseline in biomarkers of cardiovascular disease risk after treatments
Time frame: 12 and 20 weeks
Change from baseline in nutritional biomarkers after treatments
Time frame: 12 and 20 weeks
Change from baseline in blood cell gene expression after treatments
Time frame: 12 and 20 weeks
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