The aim of this study is to investigate potential metabolic effects of resveratrol in men with metabolic syndrome(otherwise healthy). The investigators hypothesize that resveratrol has an anti-inflammatory effect, and will increase insulin sensitivity, change the fat- and sugar-metabolism, and down-regulate bone-turnover.
The study will be done in a collaboration between two PhD students, who focus on effects in adipose- and muscle- tissue, and bone tissue respectively. The investigators will look at changes in * inflammation-markers * biochemical markers of fat- and sugar-metabolism * gene-expression in fat- and muscle-tissue * body composition (DXA (whole body) and MR spectroscopy) * biochemical markers of bone-metabolism * Bone Mineral Density (DXA scans) * bone structure (QCT) * gene-expression and cytokines in bone marrow Some of the volunteers will have their insulin sensitivity measured.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
QUADRUPLE
Enrollment
76
500mg resveratrol 2 times daily for 4 months (High-dose Resveratrol), 75mg resveratrol 2 times daily for 4 months (Low-dose Resveratrol) or 1 placebo 2 times daily for 4 months
Clinical Institute, Aarhus University
Aarhus, Aarhus, Denmark
Changes from Baseline in markers of inflammation (hs-CRP) in blood after 4 months of treatment with either resveratrol or placebo
Time frame: 4 months
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