The Effect of High Dose Vitamin C on the Liver Function in Chronic Hepatitis Patients

Seoul National University Hospital10 enrolled

Overview

The investigators will evaluate the efficacy of high dose vitamin C in chronic hepatitis patients whose serum liver enzymes are elevated more than upper limit.

The changes of laboratory findings including serum transaminase levels, serum albumin levels, Child-Pugh score, MELD score, and APRI score will be evaluated.

Study Type

INTERVENTIONAL

Allocation

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Chronic Hepatitis Chronic Hepatitis C Chronic Alcoholic Hepatitis

Interventions

High dose vitamin CDRUG

Vitamin C, 3g per day (tid), with meal, per oral with water 100mL

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Chronic hepatitis C patients * positive anti-HCV antibody more than 6 months * serum alanine aminotransferase 40 - 80 IU/L for more than 6 months * not indicated for antiviral therapy with interferon and ribavirin 2. Chronic alcoholic hepatitis * significant alcohol drinking history and no other cause of chronic hepatitis * serum alanine aminotransferase 40 - 80 IU/L for more than 6 months Exclusion Criteria: * Chronic hepatitis B, autoimmune hepatitis, primary biliary cirrhosis, Wilson's disease, hemochromatosis, other chronic hepatitis except chronic hepatitis C or alcoholic hepatitis * decompensated liver cirrhosis * platelet \< 50,000/uL or white blood cell \< 1,500/uL * need and willing for antiviral therapy * significant renal dysfunction (GFR \< 30 mL/min/kg) or history of renal stone * hepatotonic drug (i.e. silymarin, garlic oil, aronamin gold) usage within 2 weeks * pregnancy, lactating woman

Locations (1)

Seoul National University Hospital

Seoul, South Korea

Outcomes

Primary Outcomes

The Change in Serum Alanine Aminotransferase Level From Baseline to 12 Weeks

Serum alanine aminotransferase (ALT) level after 12 weeks of high dose vitamin C administration and Baseline serum ALT level

Time frame: Baseline and 12 weeks

Secondary Outcomes

The Change in Serum Interleukin 22 Level From Baseline to 12 Weeks

Serum interleukin 22(IL-22)level after 12 weeks of high vitamin C administration and Baseline IL-22 level

Time frame: Baseline and 12 weeks

Data from ClinicalTrials.gov

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