The purpose of this study is to compare and contrast the effects of a prebiotic (Trametes Versicolor), a probiotic (Saccharomyces boulardii) and an antibiotic (amoxicillin) on the gut microbiota of healthy volunteers. It is expected that treatment will result in the rapid and reproducible alterations in fecal microbiota that will spontaneously reverse in the weeks after treatment is discontinued.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
32
1,200 mg, 3 times daily on an empty stomach for 14 days
250 mg, 3 times daily on an empty stomach for 14 days
250 mg 3 times daily at least 1 hour before meals for 7 days
Beth Israel Deaconess Medical Center
Boston, Massachusetts, United States
Bacteria Prevalence in Stool
The most prevalent bacterial genera within the study population Before Treatment: Average of Day -7 and Day 0 During Treatment: Average of Days 10 and 14 After Treatment: Average of Days 21, 28, and 56
Time frame: Day 0 to 56
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