There is experimental evidence that low levels of adiponectin are associated with more reperfusion injury. In addition experimental studies have demonstrated that endothelial progenitor cells may have a favorable effect on remodeling, mainly through stimulation of neo-revascularisation. Clinical data on these issues are lacking. This clinical project studies the role of adiponectin, endothelial progenitor cells and endothelial microparticles in the ischaemia-reperfusion process and the compensatory ventricular remodelling in a population of 250 infarction patients treated with primary PCI. If the role of these factors could be confirmed in this clinical setting, those factors might represent a new target for therapeutic interventions in AMI patients.
Study Type
OBSERVATIONAL
Enrollment
250
University hospital
Edegem, Antwerp, Belgium
occurrence of reperfusion injury after succesfull primary PCI
Serial ECG measurements (before and after PCI to assess extent of ST segment resolution as marker of reperfusion injury
Time frame: within 90 min after PCI
Major cardiovascular event rate
combined endpoint of hospitalisation (or extension of hospitalisation) for heart failure and cardiac death in a period of one year
Time frame: at 1 year
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