GIP Effects at Insulin Induced Hypoglycemia in Patients With Type 2 Diabetes

Early Phase 1CompletedNCT01414556

Mikkel Christensen12 enrolled

Overview

Investigation of GIP effects at fasting and hypoglycemia

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

TRIPLE

Enrollment

Conditions

Type 2 Diabetes Mellitus

Interventions

Glucose-dependent Insulinotropic polypeptideOTHER

infusion 4 pmol x kg x min first 15 min, thereafter 2 pmol x kg x min

salineOTHER

Eligibility

Sex: MALEMin age: 18 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Caucasians 18 years or older with Type 2 diabetes (WHO criteria) Exclusion Criteria: * HbA1c \>9 % * Liver disease (ALAT/ASAT \>2 x upper normal limit) * Diabetic nephropathy (s-creatinine \>130 µM or albuminuria) * Proliferative diabetic retinopathy (anamnestic) * Severe arteriosclerosis or heart failure (NYHA group III og IV) * Anemia * treatment with medication not applicable to pause for 12 hours * Fasting plasma glucose \>15 mM on screening day.

Locations (1)

Gentofte Hospital

Hellerup, Denmark

Outcomes

Primary Outcomes

glucagon/insulin(c-peptide) absolute, incremental and area under curve values

Time frame: approx. 15 minutes intervals, time 0 to 120 min

Secondary Outcomes

plasma gut hormones and nutrients

Time frame: approx. 15 minutes intervals, time 0 to 120 min

Data from ClinicalTrials.gov

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