HCG Versus Spontaneous LH in Intrauterine Insemination (IUI ) Cycles

Early Phase 1CompletedNCT01414673

Universitair Ziekenhuis Brussel300 enrolled

Overview

We recently reported the superiority of the natural cycle to a natural cycle controlled by the administration of human chorionic gonadotropin (hCG) for planning the frozen-thawed embryo transfer cycles, demonstrating a probable negative impact of exogenous hCG on endometrial receptivity.Based on the above findings we conducted the first prospective study that assesses whether there is a difference in pregnancy rate after intrauterine insemination (IUI) in a natural cycle with spontaneous luteinizing hormone (LH) rise compared to natural cycles controlled by hCG for final ovulation.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

300

Conditions

Spontaneous Triggering of Ovulation vs. Administration of Human Chorionic Gonadotropin in Patients Undergoing IUI

Interventions

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 36 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * age ≤ 36 years, * regular menstrual cycles, * body mass index (BMI) between 18 and 29 kg/m², * basal levels of FSH (≤ 12 IU/l), * estradiol (≤ 80 pg/ml) and progesterone (≤ 1.6ng/ml) on day one of the cycle, normal hysterosalpingography (maximum 3 months prior starting the cycle). * The use of donor sperm was also accepted as inclusion criteria. Exclusion Criteria: * PCOS * endometriosis

HCG Versus Spontaneous LH in Intrauterine Insemination (IUI ) Cycles

Overview

Conditions

Interventions

Eligibility

Locations (1)

Outcomes

Primary Outcomes