Circulating Tumor Cells in Prostate Cancer Patients

Inclusion Criteria: Men who satisfy all of the following conditions will be eligible for this study: * Willing and capable to provide informed consent * Signed study specific informed consent form. * PSA ≤ 20 prior to hormone therapy (if given) for patients with Gleason 2-6. For those with Gleason score of 7. PSA should be less than or equal to 15 ng/ml prior to hormonal therapy (if given). Thus, risk of pelvic lymph node involvement according to Roach formula would be under 20%. * Gleason score ≤ 7 * Appropriate staging studies identifying as AJCC stage T1a, T1b, T1c, T2a, or T2b * No direct evidence of regional or distant metastases after appropriate staging studies * Histologic confirmation of cancer by biopsy * Adenocarcinoma of the prostate * Age ≥ 18 * Zubrod Performance Status 0-2 * Up to 9 months of previous hormonal therapy is allowed (but not required) * AUA score must be ≤ 15 (alpha blockers allowed) * CT or Ultrasound-based volume estimation of prostate gland ≤ 60 grams * Agreement to use effective contraceptive methods such as condom/diaphragm and spermicidal foam, intrauterine device, or prescription birth control pills. Exclusion Criteria: Women are not eligible for this study. Men with one or more of the following conditions also are ineligible for this study: * Positive lymph nodes or metastatic disease from prostate cancer * Prior invasive malignancy unless disease free for a minimum of 3 years (carcinoma in situ of the breast, oral cavity, or cervix, or non-melanomatous skin cancer are all permissible) * T2c, T3, or T4 tumors * Previous pelvic radiotherapy * Previous surgery or chemotherapy for prostate cancer * Previous transuretheral resection of the prostate (TURP) or cryotherapy to the prostate * Previous hormonal therapy given for more than 9 months prior to therapy * Concomitant antineoplastic therapy (including surgery, cryotherapy, conventionally fractionated radiotherapy, and chemotherapy) while on this protocol. * History of Crohn's Disease or Ulcerative Colitis. * Previous significant obstructive symptoms; AUA score must be ≤ 15 (alpha blockers allowed) * Significant psychiatric illness * Men of reproductive potential may not participate unless they agree to use an effective contraceptive method. * Ultrasound or CT estimate of prostate volume \> 60 grams