The Optimal Timing of Carbon Dioxide Insufflation During Colonoscopy in Unsedated Patients

Tri-Service General Hospital200 enrolled

Overview

Insufflation of carbon dioxide (CO2) instead of air can reduce pain resulting from colon distension after colonoscopy because CO2 is rapidly absorbed from the colon and excreted through the lungs. This reduces the effects of colonic distension and minimizes intracolonic gas at the end of the examination. The aims of the study were to evaluate the timing of administering CO2 insufflation and to identify predictors of discomfort for colonoscopy.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

HEALTH_SERVICES_RESEARCH

Masking

DOUBLE

Enrollment

200

Conditions

Outpatients

Interventions

Insufflation with CO2PROCEDURE

Patients were randomly allocated to receive whole procedure or extubation-only CO2 insufflation, using a randomized computer-generated list.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 90 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * patients with an appropriate indication for colonoscopy were considered eligible. Exclusion Criteria: * Exclusion criteria included severe hematochezia, acute colonic pseudo-obstruction, known obstructive lesions, age \<18 years, prior colon resection, fulminant colitis, chronic obstructive pulmonary disease requiring oxygen, and a medical history of CO2 retention. Patients that required only a partial colonoscopy or were unable to read or understand Chinese were also excluded.

Locations (1)

Division of Gastroenterology, Tri-Service General Hospital

Taipei, Taiwan

Outcomes

Primary Outcomes

abdominal pain during and after colonoscopy

Pain was recorded on a ten-point visual analog scale (0- no pain, 10- worst imaginable pain) at left-sided colonoscopic insertion, right-sided colonoscopic insertion, and at 1, 3, 6, and 24 hours postprocedure.

Time frame: One day

Secondary Outcomes

delayed bleeding

Time frame: One day

colonoscopic cecal intubation time

Time frame: One day

completeness of intubation

Time frame: One day

loop formation

Time frame: One day

Data from ClinicalTrials.gov

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