The purpose of this study in healthy people is to evaluate safety, toleration and time course of plasma concentration of single inhaled doses of PF-05212372.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Enrollment
24
Inhaled. Dose Level 1: 50 ug
Inhaled. Dose Level 2 - Dose to be selected based upon safety/tolerability/PK at preceding dose
Inhaled. Dose Level 3 - Dose to be selected based upon safety/tolerability/PK at preceding dose
Pfizer Investigational Site
Brussels, Belgium
Number of Participants with Adverse Events as a Measure of Safety and Tolerability
Time frame: 14 days
Plasma pharmacokinetics
Time frame: up to 72 hours post dose
Urine pharmacokinetics
Time frame: up to 24 hours post dose
Urine Pharmacodynamics
Time frame: up to 24 hours post dose
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Inhaled. Dose Level 4 - Dose to be selected based upon safety/tolerability/PK at preceding dose
Inhaled
Inhaled. Dose Level 5 - Dose to be selected based upon safety/tolerability/PK at preceding dose
Inhaled. Dose Level 6 - Dose to be selected based upon safety/tolerability/PK at preceding dose
Inhaled. Dose Level 7 - Dose to be selected based upon safety/tolerability/PK at preceding dose
Inhaled