Feasibility, Efficacy, and Safety of Venous Ulcer Treatment Using a Hand Plasma Generator (PlasmaDerm) Chronisch venöser Ulzerationen (PlasmaDerm)

Inclusion Criteria: * persons of both gender aged 50 and older; females must be in menopause for at least one year * at least one chronical venous ulcerisation at one or both legs with the following characteristics: size between 5 cm² and 30 cm²; duration 12 weeks to 10 years; located between knee and ankle; dermis and subkutis being involved, without damage of muscles, bones or tendon * vital wound ground with granulation tissue * proof of ulcerisation caused by venous malformation by duplex sonography, the tibiobrachiale index being between 0.8 and 1.3 * no active wound treatment one week before study treatment starts Exclusion Criteria: * females not being in menopause * non-venous cause for ulzerisation * lymphatic oedema, wound infection, necrotic tissue, venous fistula, bradytrophe wound ground * clinical treatment of the venes during the last three months * background therapy with systemic corticosteroides above Cushing-level (7.5 mg Prednisolonequivalent) * previous radiation treatment of the ulzerisation area * patients with defibrillator, after organ transplantation, cardiac insufficiency, known connective tissue disease, malnutrition (Albumin i.S. \< 2.5 g/dl), Diabetes mellitus (HbA1c \> 8%), active maligne disease, severe rheumatoide arthritis, hemodialysis, active sickle cell anemia * known alcohol or drug abuse * patients currently participating or having participated during the last 4 weeks in another clinical trial * patients being unable to understand the intention of the clinical trial * patients being not compliant or not being independant from the sponsor or investigator * missing approval to collect and process pseudomized data * hospitalization in a mental institution due to § 20 MPG