Oral Mucosal Absorption of ICI176,334-1

Inclusion Criteria: * Provision of signed and dated, written informed consent prior to any study specific procedures * Japanese healthy male subjects aged 20 to 45 years * Male subjects should be willing to use barrier contraception ie, condoms, until 3 months after the last dose of investigational product * Have a body mass index (BMI) between 17 and 27 kg/m2 * Eligible based on the physical findings, supine BP, pulse rate, ECG and laboratory assessments, as judged by the investigator(s) Exclusion Criteria: * Presence of any disease under medical treatment * History or presence of cardiovascular, respiratory, hepatic, renal, gastrointestinal, immunological, blood, endocrine, neurological or mental disease to interfere with absorption, distribution, metabolism or excretion of drugs judged by investigator(s) * Presence of any infectious disease, such as bacteria, virus and fungus Presence of allergic disorder, such as asthma, pollen disease or atopic dermatitis, and judged as necessary any medical treatment * Any large surgical history of gastrointestinal tract such as gastric/intestinal resection or suturation