Trial of pasireotideLAR and Topotecan in Relapsed or Refractory Small Cell Lung Cancer

Inclusion criteria 1. Histologically documented SCLC failed one chemotherapy with documentation of relapse or progressive disease. 2. Measurable or evaluable disease by CT scan. If evaluable disease or measurable disease has been previously treated, this must show signs of tumor progression by CT. 3. Karnofsky performance status of 80, Age ≥ 18 years and life expectancy of ≥12 weeks 4. Minimum of four weeks since any major surgery, completion of radiation or chemotherapy 5. ANC ≥ 1.5 x 109/L, Platelets ≥ 100 x 109/L, Hgb \> 9 g/dL. 6. Serum bilirubin ≤ 2 x upper limit of normal (ULN), and serum transaminases activity ≤ 3 x ULN, with the exception of serum transaminases (\< 5 x ULN) if the patient has liver metastases. Serum creatinine ≤ 1.5 x ULN. 7. Fasting serum cholesterol ≤300 mg/dL OR ≤7.75 mmol/L AND fasting triglycerides ≤ 2.5 x ULN. NOTE: If exceeded, the patient can only be included after initiation of appropriate lipid lowering medication. 8. Women of childbearing potential must have a negative serum pregnancy test within 14 days of the administration of the first study treatment. Women must not be lactating. 9. Signed informed consent to participate in the study must be obtained from patients after they have been fully informed of the nature and potential risks by the investigator (or his/her designee) with the aid of written information. Exclusion criteria 1. Prior topotecan or prior octreotide therapy. 2. Chronic treatment with systemic steroids or another immunosuppressive agent. 3. Patients should not receive immunization with attenuated live vaccines during study period or within 1 week of study entry. 4. Uncontrolled brain or leptomeningeal metastases. 5. Patients with prior or concurrent malignancy except for the following: adequately treated basal cell or squamous cell skin cancer, or other cancer from which the patient has been disease free for five years. 6. Patients with uncontrolled diabetes mellitus or a fasting plasma glucose \> 1.5 ULN.. 7. Patients with symptomatic cholelithiasis. 8. Patients who have congestive heart failure, unstable angina, sustained ventricular tachycardia, ventricular fibrillation, clinically significant bradycardia, advanced heart block or a history of acute myocardial infarction within the six months preceding enrollment. 9. Patients who are at high risk for cardiac arrhythmias as defined by any of the following: * Baseline QTcF \> 450 msec * History of syncope or family history of idiopathic sudden death or long QT syndrome * Sustained or clinically significant cardiac arrhythmias * Risk factors for Torsades de Pointes such as hypokalemia, hypomagnesemia, cardiac failure, clinically significant/symptomatic bradycardia, or high-grade AV block * Concomitant disease(s) that could prolong QT such as autonomic neuropathy (caused by diabetes, or Parkinson's disease), HIV, cirrhosis, uncontrolled hypothyroidism or cardiac failure * Concomitant medication(s) known to increase the QT interval 10. Patients taking concomitant medications that are at risk of prolonging QT interval. If patient is to be included in the study, these medications need to be discontinued 11. Patients with the presence of active or suspected acute or chronic uncontrolled infection or with a history of immunocompromise, including a positive HIV test result 12. None malignant disease that are uncontrolled such as severe impaired lung function. 13. Women who are pregnant or breast feeding, or women/men able to conceive and unwilling to practice an effective method of birth control. (Women of childbearing potential must have a negative serum pregnancy test within 14 days prior to administration of pasireotide). Oral, implantable, or injectable contraceptives may be affected by cytochrome P450 interactions, and are therefore not considered effective for this study. 14. Known hypersensitivity to somatostatin analogues or any component of the pasireotide or octreotide LAR formulation