Heart Failure with Preserved Ejection Fraction (HFpEF) and Pulmonary Hypertension (PH) can be diagnosed noninvasively by Exercise Echocardiography (ExE) and Cardiopulmonary Exercise Testing (CPX) as compared with gold standard invasive hemodynamic assessment.
* The broad objective of this proposal is to characterize the dynamic changes in cardiopulmonary mechanics during stress in patients with exertional dyspnea, establishing a comprehensive multimodality diagnostic approach to the evaluation of exercise intolerance. * The specific objective is to prospectively compare established and novel parameters derived from echocardiography and CPX with simultaneous, gold standard invasive measures of cardiovascular hemodynamics at rest and with exercise stress to define the role of noninvasive testing in the diagnostic workup. * The primary hypothesis is that combined ExE and CPX can noninvasively identify HFpEF.
Study Type
OBSERVATIONAL
Enrollment
108
Mayo Clinic
Rochester, Minnesota, United States
Diagnostic Utility ExE and CPX
Time frame: Same day as clinically indicated Right Heart Catheterization (RHCath)
Multiple integrated measures of cardiovascular function derived from RHCath, ExE and CPX along with rest/exercise natriuretic peptide levels
Time frame: Same day as clinically indicated RHCath
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