SYMPLICITY HTN-3 Renal Denervation in Patients With Uncontrolled Hypertension

Inclusion Criteria: * Individual is ≥ 18 and ≤ 80 years old at time of randomization. * Individual is receiving a stable medication regimen including full tolerated doses of 3 or more anti-hypertensive medications of different classes, of which one must be a diuretic (with no changes for a minimum of 2 weeks prior to screening) that is expected to be maintained without changes for at least 6 months. * Individual has an office systolic blood pressure (SBP) of ≥ 160 mmHg based on an average of 3 blood pressure readings measured at both an initial screening visit and a confirmatory screening visit Exclusion Criteria: * Individual has an estimated glomerular filtration rate (eGFR) of \< 45 mL/min/1.73 m2 * Individual has an Ambulatory Blood Pressure Monitoring (ABPM) 24 hour average SBP \< 135 mmHg * Individual has type 1 diabetes mellitus * Individual requires chronic oxygen support or mechanical ventilation (e.g., tracheostomy, CPAP, BiPAP) other than nocturnal respiratory support for sleep apnea. * Individual has primary pulmonary hypertension. * Individual is pregnant, nursing or planning to be pregnant.