Comparison of Conventional Triple Therapy Versus Sequential Therapy for H. Pylori in Peptic Ulcer Disease: Prospective Randomized Trial

Jun-Won Chung159 enrolled

Overview

The purpose of this study is to improve first line Helicobacter pylori eradication rate and to compare the sequential versus conventional triple therapy.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

159

Conditions

Helicobacter Infected Patients

Interventions

sequential versus tripleDRUG

sequential: lansoprazole 30mg bid+amoxicillin 100mg bid for first five day lansoprazole 30mg bid+clarithromycin 500mg bid+metronidazole 500mg for 5day conventional tripe lansoprazole 30mg bid+clarithromycin 500mg bid+amoxicillin 1000mg bid

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * peptic ulcer diseae * two test positive rapid urease test, culture, histology Exclusion Criteria: * lactating or pregnant * previous stomach surgery * severe underlying disease

Locations (1)

Gil Medical Center

Incheon, South Korea

Outcomes

Primary Outcomes

the eradication rate by urea breath test

to compare the eradication rate (intention-to-treat and per protocol) by urea breath test at least four weeks after treatment

Time frame: 4-6 week later after completion of therapy

Data from ClinicalTrials.gov

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