In this experimental study on healthy volunteers we explored the effect of pregabalin alone and in combination with remifentanil on acute experimental pain and ventilatory function.
Pain during cold pressor test (CPT) was scored at all dose levels of remifentanil on a visual analogue scale (VAS 0-100 mm). Ventilatory function was measured by spirometry registering respiratory frequency (breaths/min), minute volume (L/min) and expiratory end-tidal carbon dioxide tension (mmHg). Side effects such as nausea and sedation were registered.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
12
hard capsule, 150 mg, 2 times, 2 days
50-90 min: TCI 0.6 ng/mL, 100-140 min: 1.2 ng/mL, 150-190 min: TCI 2.4 ng/mL
hard capsule, 150 mg, 2 times, 2 days, saline infusion
Oslo Universitetssykehus, Rikshospitalet
Oslo, Norway
Pain intensity
Pain was caused by Cold Pressure Test
Time frame: 123 sec x 4
Ventilatory function
Respiratory frequence (breath/min), tidal volume (mL), minute volume (L)and expiratory end-tidal carbon dioxide tension (mmHg)
Time frame: 10 min x 4
Cognitive function
Cognitive function was tested using pc-tests like Cambridge Neuropsychological Test Automated Battery (CANTAB) and Stroop-test
Time frame: 4 min x 4
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