The goal of this study is to calculate pharmacokinetic parameters and to evaluate the trough levels of posaconazole reached in patients with different stages of mucositis, due to chemotherapy and total body irradiation.
Study Type
OBSERVATIONAL
Enrollment
55
During posaconazole treatment, blood sampling will occur on day 0 (=day of transplantation), day 7 and 14 to correlate posaconazole exposure to severity of mucositis.
University Hospitals Leuven
Leuven, Vlaams-Brabant, Belgium
RECRUITINGPosaconazole plasma levels and area under the curve in patients with different stages of mucositis
Plasma levels of posaconazole will be determined to calculate the area under the curve. These values will be correlated with the stage of mucositis, which will be assessed using citrulline monitoring in plasma. The stage of mucositis will also be assessed using the Daily Oral Mucositis Score (DMS) and Daily Gut Mucositis Score (DGS).
Time frame: Day 0 (day of transplantation), day +7, day +14
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