The main objective of this research project is to provide a comprehensive clinical database of patients with Alzheimer's disease (AD) and other forms of dementia, individuals with mild cognitive impairment (MCI), and age-matched normal controls. The study will also attempt to identify cognitively normal individuals at genetically defined risk for Alzheimer's disease through genetic screening. All participants are seen annually. Autopsies to establish diagnoses in patients with dementia, patients with mild MCI, and cognitively normal elderly control subjects will also be conducted.
All participants are seen annually. In addition to a detailed neurological examination, participants will receive a standardized battery of neuropsychological tests and will undergo genetic testing. The investigators will provide standardized periodic longitudinal assessment of the research participants. Autopsies to establish neurohistopathological diagnoses in clinically well-characterized patients with dementia, patients with mild MCI, and cognitively normal elderly control subjects will also be conducted.
Study Type
OBSERVATIONAL
Enrollment
900
University of Arizona, University Medical Center
Tucson, Arizona, United States
RECRUITINGNeuropsychological Test Scores
Cognitive function will be evaluated on a yearly basis using a battery of neuropsychological tests, which will then be scored and normed according to established guidelines.
Time frame: Up to 20 years
Neurological Exam
A thorough neurological exam will be performed once per year to evaluate neurological function.
Time frame: Up to 20 Years
Brain Tissue
A brain autopsy will be performed upon the participant's death to establish histological diagnosis.
Time frame: From date of entry until date of death assessed up to 20 years
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