Effects of Clopidogrel and Clarithromycin on the Oral Disposition of Sibutramine in Healthy Subjects

Inje University20 enrolled

Overview

Effects of clopidogrel and clarithromycin on the oral disposition of sibutramine in healthy subjects

1\. Plasma concentrations of sibutramine and its two active metabolites after single oral dose of sibutramine were determined in Korean healthy male subjects with different CYP2B6 genotypes (CYP2B6\*1/\*1, \*1/\*6 and \*6/\*6), either alone or after four-day pretreatment with clopidogrel or clarithromycin.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Masking

NONE

Enrollment

Conditions

Healthy

Interventions

Sibutramine-clopidogrelDRUG

Sibutramine-clopidogrel

sibutramine-ClarithromycinDRUG

sibutramine-Clarithromycin

Eligibility

Sex: MALEMin age: 19 YearsMax age: 55 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * must be healthy volunteer Exclusion Criteria: * must not be under 18 years old

Outcomes

Primary Outcomes

effects of clopidogrel and clarithromycin on the disposition of sibutramine

the effects of clopidogrel and clarithromycin on the disposition of sibutramine and its two active metabolites M1 and M2 in vivo in relation to CYP2B6\*6 genetic polymorphism have been evaluated in Korean healthy subjects.

Time frame: one year

Data from ClinicalTrials.gov

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