This study will test whether short-term suppression of ovarian function can ameliorate androgen (male hormone) overproduction in overweight girls with androgen excess. The investigators hypothesize that one dose of depot leuprolide agonist administration will improve androgen levels in girls with ovarian androgen overproduction. Specifically, this intervention will improve androgen levels after ovarian stimulation testing with recombinant human chorionic gonadotropin (rhCG).
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
depot leuprolide 11.25 mg if less than or equal to 37.5 kg or 15 mg if \> 37.5 kg im once
University of Virginia Center for Research in Reproduction
Charlottesville, Virginia, United States
17 hydroxyprogesterone responses to rhCG before and 4 weeks after depot leuprolide administration
Time frame: 4 weeks after leuprolide
Ovarian hormone precursor responses to rhCG before and 4 weeks after depot leuprolide administration
Time frame: 4 weeks after leuprolide
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