The objective of this study is to compare pharmacokinetics after single oral administration of 2 capsules of YH14659, a fixed-dose combination of clopidogrel and aspirin developed by Yuhan Corporation versus co-administration of Plavix (clopidogrel) and Astrix (aspirin) in healthy male volunteers.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
44
YH14659 capsule by oral
clopidogrel tablet(75mg) + aspirin capsules(100mg) by oral
Yuhan Corporation
Seoul, South Korea
Maximum plasma concentration(Cmax) of clopidogrel
Time frame: 14 days
Area under the time-concentration curve to last concentration(AUCt) of clopidogrel
Time frame: 14 days
Maximum plasma concentration(Cmax) of acetylsalicylic acid
Time frame: 14 days
Area under the time-concentration curve to last concentration(AUCt) of acetylsalicylic acid
Time frame: 14 days
Cmax of salicylic acid, the major active metabolite of aspirin
Time frame: 14 days
AUCt of salicylic acid, the major active metabolite of aspirin
Time frame: 14 days
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