Changes of the Peripapillary Retinal Nerve Fiber Layer After Filtration Surgery in Glaucoma Patients

University Eye Hospital, Würzburg12 enrolled

Overview

At present, trabeculectomy is the most common performed and effective surgical method of filtration surgery for patients with medically uncontrolled glaucoma. The aim of this prospective observational case study is to determine changes of the peripapillary retinal nerve fiber layer thickness using spectral domain optical coherence tomography in patients with glaucoma after surgical reduction of intraocular pressure.

Baseline and postoperative measurement of the peripapillary retinal nerve fiber layer (RNFL) thickness will be performed using the following spectral domain optical coherence tomography (OCT): Cirrus™ HD-OCT (Carl Zeiss Meditec) and Spectralis® Heidelberg-Engineering. The main outcome measures will be changes in overall and quadrant RNFL thickness with respect to reduction in intraocular pressure (IOP), correlation between RNFL thickness and alteration in visual field and predictive factors of postoperative IOP-reduction and changes of RNFL thickness.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Nerve Fiber Bundle Defect Optic Nerve Diseases

Interventions

spectral domain optical coherence tomographyPROCEDURE

RNFL thickness measurement using spectral domain optical coherence tomography at baseline, 1, 3 and 6 months postoperatively.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * primary or secondary open angle glaucoma * target intraocular pressure under medical treatment was not reached * progression of visual loss * best corrected visual acuity of 20/100 or more * spherical equivalent refraction of -8.0 to +4.0 D * perimetry: less than 20% false positive answers Exclusion Criteria: * primary or secondary angle closure glaucoma * congenital glaucoma * normal tension glaucoma * neovascular glaucoma

Locations (1)

University Eye Hospital Wuerzburg

Würzburg, Bavaria, Germany

Outcomes

Primary Outcomes

change of retinal nerve fiber layer thickness

study was terminated

Time frame: 6 months

Data from ClinicalTrials.gov

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