Safety and Efficacy Study of Combretastatin A4 Phosphate to Treat Patients With Choroidal Neovascularization Secondary to Pathologic Myopia

Inclusion Criteria: * Provide written informed consent * Be able and willing to follow instructions * Age 18 to 50 years old (inclusive) * Have area of CNV within 50 um or under the geometric center of the foveal avascular zone Have greatest linear dimension of lesion 5,400 um or less, with \>/=50.0% of the lesion composed of CNV (features which obscure the boundaries of the CNV such as blood, serous pigment epithelial detachment or blocked fluorescence must occupy \<50.0%) as confirmed by Doheny Image Reading Center (DIRC) * Have best corrected distance visual acuity (ETDRS) of 20/20 to 20/200 (LogMAR +0.0 to 1.0), inclusive in the qualifying eye(s) * Have pathologic myopia presenting - 6.0 diopters or more correction required OR an axial length of the \>/= 26.5 mm * Be able and willing to avoid any medication that the investigator feels may interfere with the study * If female and of childbearing potential, agree to submit a sample for pregnancy testing and have a negative pregnancy test within 1 day prior to each treatment. Females are considered of childbearing potential unless they are surgically sterile or post-menopausal for 12 months. Females of childbearing potential must agree to an approved form of contraception for the duration of the study. Exclusion Criteria: * Have contraindications, allergies or sensitivity to the use of the study medications * Have clinical signs or symptoms, in the opinion of the investigator, that may interfere with the study * Features of any condition other than pathologic myopia associated with CNV, such as age-related macular degeneration * Have a tear of the retinal pigmented epithelium * Have undergoing ocular therapy/surgery or major surgery in the last 3 months or have any surgeries planned during the study period * Have any significant illness or condition, ocular or systemic that could, in the opinion of the investigator, be expected to interfere with the study * Have angina (stable or severe, even if controlled with medications), 6 months S/P myocardial infarction ,congestive heart failure, history of or presence of any clinically significant supraventricular or ventricular arrhythmias or syncope episodes * Have ECG with QTc \>450 msdec or other clinically significant abnormalities such as left bundle branch block, left ventricular hypertrophy, etc. * Have uncontrolled QTc prolongation * Take any drugs known to prolong the QTc interval however subject can remain eligible if a non-QTc substitute can be administered * Have uncontrolled hypertension (defined as blood pressure consistently greater than 150/100 mm Hg irrespective of medication) * Uncontrolled hypokalemia and/or hypomagnesemia * Have symptomatic peripheral vascular disease or cerebrovascular disease * Have psychiatric disorders or other conditions rendering subjects incapable of complying with the requirements of the protocol * Be receiving concurrent hormonal therapy with exception of Gonadotropin-releasing hormone agonists in subjects with hormone refractory prostate cancer, hormone replacement therapy, oral contraceptive, and megestrol acetate used for anorexia/cachexia * Be receiving anticoagulation with warfarin, heparin or low molecular weight heparin other than low dose (1 mg) warfarin for maintenance of Hickman line patency * Be a woman who is currently pregnant, nursing, or planning a pregnancy; or woman who has a positive pregnancy test * Have participated in an investigational drug or device trial within 30 days of entering the study