The purpose of this study is to compare the toxicity of two new radiation schedules for the treatment of prostate cancer. Patients will be randomized to receive 5 treatments delivered every other day over 11 days, or once per week over 29 days. Both of these schedules are shorter than the standard treatment which is usually 39 treatments over 8 weeks.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
152
40 Gy / 5 fractions / 11 days
40 Gy / 5 fractions / 29 days
BC Cancer Agency - Abbotsford Centre
Abbotsford, British Columbia, Canada
CancerCare Manitoba
Winnipeg, Manitoba, Canada
Sunnybrook Health Sciences Centre
Toronto, Ontario, Canada
Bowel related quality-of-life
Time frame: 3 months
Gastrointestinal toxicity
Radiation Therapy Oncology Group Acute and Late Morbidity Scoring Schema
Time frame: During radiotherapy, at 3 and 6 months, then every 6 months after
Genitourinary toxicity
Radiation Therapy Oncology Group Acute and Late Morbidity Scoring Schema
Time frame: During radiotherapy, at 3 and 6 months, then every 6 months after
PSA relapse rate
Time frame: 3 and 5 years
Patient Overall Quality of life
Time frame: During radiotherapy, at 3 and 6 months, then every 6 months after
Salvage androgen deprivation therapy rate
Time frame: 3 and 5 years
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