TLR-9 Antagonism in Steroid Resistant Optic Neuritis

Sudhalkar Eye Hospital8 enrolled

Overview

Although idiopathic steroid resistant optic neuritis is very uncommon, there is no established treatment protocol for such patients. Toll like receptors (TLRs) especially TLR-9 has been shown to play a role in the pathogenesis of optic neuritis. This small case series aims to determine whether immunomodulators directed specifically at TLR-9(i.e. TLR-9 antagonism)play any role in improving the visual function in such patients.

Study Type

INTERVENTIONAL

Allocation

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Optic Neuritis

Interventions

Mycobacterium w.(Mw)-freeze dried extract 0.5mlDRUG

0.5 ml of Mw in 500ml 0.9% normal saline administered over two hours as an infusion. 2ml(4mg/ml) of dexamethasone administered two hours prior to Mw administration

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: Unilateral Steroid Resistant Optic Neuritis Exclusion Criteria: * bilateral optic neuritis * Associated Systemic disease * Prior treatment received

Locations (1)

Sudhalkar Eye Hospital

Vadodara, Gujarat, India

Outcomes

Primary Outcomes

Improvement in all aspects of visual function

Time frame: upto 6 months

Data from ClinicalTrials.gov

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