NCT01425138 - Systematic Review And Meta-Analysis Of Psoriasis Treatments. | Crick

Overview

This project involved a systematic literature review of published trials of treatments for moderate-to-severe plaque psoriasis. Data was extracted from the publications on various psoriasis endpoints including the Physician Global Assessment (PGA), Dermatology Life Quality Index (DLQI), and Short-Form 36 (SF-36). A traditional meta-analysis and a mixed treatment comparison was conducted on the extracted data.

This project involved a systematic literature review of published trials of treatments for moderate-to-severe plaque psoriasis. Data was extracted from the publications on various psoriasis endpoints including the Physician Global Assessment (PGA), Dermatology Life Quality Index (DLQI), and Short-Form 36 (SF-36). A traditional meta-analysis and a mixed treatment comparison was conducted on the extracted data. We included all published randomized controlled trials of treatments for moderate-to-severe psoriasis that met the study inclusion criteria.

Study Type

OBSERVATIONAL

Enrollment

1

Conditions

Psoriasis

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Randomized controlled clinical trials of treatments for moderate-to-severe plaque psoriasis. * Trials had to evaluate at least one of the following: Physician's Global Assessment (PGA), Dermatology Life Quality Index (DLQI) and/or the Short-Form 36 (SF-36). Exclusion Criteria: Observational studies * Trials that did not report the Physician's Global Assessment (PGA), * Dermatology Life Quality Index (DLQI) or the Short-Form 36 (SF-36).

Outcomes

Primary Outcomes

Physician Global Assessment (PGA)

Dermatology Life Quality Index (DLQI)

Short-Form 36 (SF-36)

Secondary Outcomes

No secondary outcomes

Time frame: No secondary outcomes