This study will investigate the pharmacokinetics, safety and tolerability of dapsone and adapalene following topical administration of 2 formulations of dapsone/adapalene fixed combination gel, dapsone 5% gel (ACZONE®), and adapalene 0.3% gel (Differin®) in subjects with acne vulgaris.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Masking
TRIPLE
Study medication will be applied once daily for 14 days to the face, upper chest, upper back, and shoulders.
Study medication will be applied once daily for 14 days to the face, upper chest, upper back, and shoulders.
Study medication will be applied twice daily for 14 days to the face, upper chest, upper back, and shoulders.
Plasma Levels of Dapsone
Time frame: Day 1
Plasma Levels of Dapsone
Time frame: Day 14
Plasma Levels of Adapalene
Time frame: Day 1
Plasma Levels of Adapalene
Time frame: Day 14
Local Dermal Tolerability Rating Using a 4-Point Scale
Time frame: Day 14
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Study medication will be applied once daily for 14 days to the face, upper chest, upper back, and shoulders.