A Trial to Evaluate the Effect of Rosuvastatin on Inflammation in Patients Undergoing Isolated Cardiac Valve Surgery

Inclusion Criteria: * Single or multiple valve repairs or replacements without coronary artery bypass grafting * Bentall procedure, but no other aortic procedures * With or without accompanying MAZE procedure (surgical treatment for atrial fibrillation) Exclusion Criteria: * Age under 18 years old * Urgent or emergency surgery * Unable to provide consent * Presently on statin therapy or exposure to statins within a month of surgery * Chronic anti-inflammatory use, including steroids and NSAID's (nonsteroidal anti-inflammatory drugs) (not to be used during the treatment period) * Known hypersensitivity to rosuvastatin * Active liver disease Indicated by AST/ALT higher than 3 times the upper limit of normal * Pregnant or nursing women * On drugs with interactions (Cyclosporine, gemfibrozil, lopinavir/ritonavir or atazanavir/ritonavir, niacin) Severe renal impairment not on dialysis * Creatinine clearance \< 30 ml/min/1.73 m2 * Known myopathy and inflammatory diasthesis (such as systemic lupus erythromatosus, rheumatoid arthritis, and inflammatory bowel disease) * Human Immunodeficiency Virus