Effect of Valsartan on Left Ventricular Myocardial Functions in Hypertensive Patients With Left Ventricular Hypertrophy

Mustafa Kemal University38 enrolled

Overview

The study hypothesis: Valsartan as an angiotensin II receptor blocker treatment has beneficial effects on both midwall mechanics and myocardial functions in hypertensive patients with Left ventricular hypertrophy.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Hypertension Left Ventricular Hypertrophy

Interventions

valsartanDRUG

80/160 mg dosage of valsartan or 160+12,5 mg valsartan+hydrochlorothiazide combination, once a day, for six months

Eligibility

Sex: ALLMin age: 18 YearsMax age: 75 Years

Medical Language ↔ Plain English

Inclusion Criteria: * hypertension with left ventricular hypertrophy Exclusion Criteria: * clinical or laboratory evidence of secondary hypertension * heart failure * ischemic heart disease * valvular heart disease * arrhythmias * peripheral vascular disease * chronic obstructive pulmonary disease * neurologic disorders * diabetes mellitus * renal dysfunction * notable systemic disease

Locations (1)

Mustafa Kemal University School of Medicine, Department of Cardiology

Antioch, Antioch, Turkey (Türkiye)

Outcomes

Primary Outcomes

change from baseline in midwall fractional shortening (mFS) and tissue Doppler systolic wave (Sm) measured by echocardiography at six months

Time frame: six months

Secondary Outcomes

change from baseline in systolic and diastolic blood pressure at six months

Time frame: six months

change from baseline in left ventricular mass index measured by echocardiography at six months

Time frame: six months

Data from ClinicalTrials.gov

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