Protein Expression in Samples From Young Patients With Rhabdomyosarcoma

Children's Oncology Group77 enrolled

Overview

RATIONALE: Studying tissue samples from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. It may also help doctors find better ways to treat cancer. PURPOSE: This research trial studies protein expression in samples from young patients with rhabdomyosarcoma.

OBJECTIVES: * To measure the protein expression of candidate proteins in human rhabdomyosarcoma (RMS) tumor samples. OUTLINE: Archived tumor tissue samples are analyzed for protein expression (i.e., Notch1, Hey1, FGFR4, and Sp1) by IHC techniques and standard commercially available antibodies. Candidate proteins are then correlated with each patient age, gender, rhabdomyosarcoma (RMS) tumor stage, and RMS tumor subtype.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Sarcoma

Interventions

protein expression analysisGENETIC

immunohistochemistry staining methodOTHER

laboratory biomarker analysisOTHER

Eligibility

Sex: ALL

Medical Language ↔ Plain English

DISEASE CHARACTERISTICS: * Tumor tissue samples from children with rhabdomyosarcoma (RMS) enrolled in the Children's Oncology Group clinical trials * Alveolar rhabdomyosarcoma (ARMS) * Embryonal rhabdomyosarcoma (ERMS) PATIENT CHARACTERISTICS: * Not specified PRIOR CONCURRENT THERAPY: * Not specified

Outcomes

Primary Outcomes

RMS protein expression profile

Data from ClinicalTrials.gov

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