rTMS-induced Cumulative Pattern of sBDNF in Chronic Schizophrenia

Jeonbuk Provincial Maeumsarang Hospital21 enrolled

Overview

This study aims at investigating the neuroplastic potential and the possible factors affecting rehabilitation in chronic schizophrenia patients on stable medication, by investigating the cumulative pattern of serum BDNF representing the neuroplasticity in the brain, through quantitative stimulus such as rTMS.

Subjects who have been enrolled for this study will take baseline evaluation for sociodemographic data and serum level of BDNF, plasma Prolaction, and magnesium, etc. And then, weekday regular stimulation through rTMS will be applied on DLPFC of brain. After the completion of stimulation for 2 weeks, the change or response of serum BDNF will be analyzed and compared.

Study Type

INTERVENTIONAL

Allocation

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Schizophrenia

Interventions

CR Technology, TAMAS for repetitive TMSDEVICE

repetitive TMS, lef DLPFC, 20Hz, 100% of MEP, 2weeks

Eligibility

Sex: ALLMin age: 25 YearsMax age: 60 Years

Medical Language ↔ Plain English

Inclusion Criteria: * duration of illness over 10 years * on stable medication, antipsychotics * no change on medication within at least 2 weeks * Diagnosis of Schizophrenia according to DSM-IV-TR Exclusion Criteria: * left or both-handedness * anticonvulsant use * lorazepam equivalent over 3 mg

Locations (1)

Jeonbuk Provincial Maeumsarang Hospital

Wanju, Jeollabuk-do, South Korea

Outcomes

Primary Outcomes

change from baseline of serum BDNF concentration

Time frame: baseline-1 week-2 week-4 week

Data from ClinicalTrials.gov

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