Analgesic Efficacy and Management of Opioid-induced Constipation (OIC) for Uncontrolled Moderate - Severe Low Back Pain

Inclusion Criteria include: * Male and female subjects ≥ 18 years of age with moderate to severe, chronic low back pain (lasting at least several hours daily) as their predominant pain condition for at least 3 months prior to screening period; * The low back pain must be related to nonmalignant and nonneuropathic conditions and may be with or without radiation; * Subjects must have a self-reported history of opioid induced constipation (OIC). Exclusion Criteria include: * Subjects with rheumatoid arthritis or other inflammatory arthritis; * Subjects with neuropathic conditions that have been painful or required therapy within the past 3 months; * Subjects with evidence of significant structural abnormalities of the gastrointestinal (GI) tract or other significant conditions affecting GI motility; * Subjects with chronic constipation not related to opioid use; * Subjects who had surgical procedures directed towards the source of chronic low back pain within 6 months of the screening visit or planned during the study; * Subjects with a history of malignancy within the past 2 years, with the exception of basal cell carcinoma that has been successfully treated. Other protocol specific inclusion/exclusion criteria may apply.